JCARM Journal of Contemporary Academic Research and Methodologies JCARM 3139-7247 Ivory and Finch Publishers 10.5281/zenodo.23279215 JCARM_SEP_26_020 Review Article Stem Cell in Regenerative Medicine and Personalized Therapeutics Verma Shiva https://orcid.org/0009-0008-3445-287X School of Health Sciences and Technology, Indian Institute of Technology Guwahati, Assam, India sv4383411@gmail.com Jee Tiwari Gopal https://orcid.org/https://orcid.org/0009-0003-2591-7237 Assistant Professor, Department of Biotechnology, Goel Institute of Technology & Management Lucknow U.P. India Shukla Saral https://orcid.org/https://orcid.org/0009-0006-1479-2469 Department of Biotechnology, Indian Institute of Technology Hyderabad, Sangareddy, Telangana, India Singh Shraddha https://orcid.org/https://orcid.org/0009-0007-2870-8309 Department of Zoology, University of Allahabad, Prayagraj, Uttar Pradesh, India Veeranan Shanmugapriyan https://orcid.org/https://orcid.org/0009-0002-4404-1827 Department of Plant Biotechnology, Tamil Nadu Agricultural University, Tamil Nadu, India 10 10 2026 1 8

Stem cells in regenerative medicine have become key players, strong potential for tissue or organ repair, replace and regenerate, disease modelling, and new therapeutics approach. Ability to self-renew and differentiate into multiple desired cell lineages ,making it more valuable for treating wide range of diseases including cardiovascular diseases, osteoarthritis disorder, neurodegenerative disorders and also in cancer. Recent research and innovation progress in pluripotent stem cells technologies, special induced pluripotent stem cells (iPSCs). have enabled therapeutics in new era of medicines. Inclusion of stem cell research with personalized medicine is supporting development of precise targeted and effective treatments with lesser side effects. Advanced technique and innovation like organoids, 3D bioprinting, disease model and organ-on-chip systems, along with biomaterial enhancement, scaffold and extracellular vesicles, improving application of the stem cells in both research and innovation as well as clinical application. Technologies provide more realistic human tissue models and improve prediction of treatment outcomes via disease models which one directly supports clinical trials. Rather than these advancements, lots of challenges remain, including standard compliance and regulatory limitations. Critical examination of translational barriers and future directions necessary to realise full clinical potential of stem cell technologies, in regenerative medicine and personalized therapeutics. Very essential to continue this interdisciplinary research and innovation with advancing safety, effectiveness and patient-specific regenerative therapies.

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